Engadget giveaway: win a G3 smartphone courtesy of LG!

As the classic refrain goes, three is a magic number — and that certainly sums up LG’s latest smartphone, the G3. It’s fronted by an extra-sharp, 5.5-inch quad HD (2,560 x 1,440) display and wrapped in a smooth metal exterior. The G3′s rear button…

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/uan6m1962bI/
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Nyko is ready to give your PS4 controller the battery life it deserves

Although the PlayStation 4 is a fine gaming console, it has a definite Achilles’ heel — the very, very short battery life of the bundled DualShock 4 controller. It’s a good thing, then, that Nyko has at last shipped the PowerPak add-on that it…

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/xS-sqQzSw4Q/
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Deal of the Day: Griffin Technology Reveal Case for iPhone 5/5S

For today only, buy the Griffin Technology Reveal Case for iPhone 5/5S and save 40%

The back of this case is made of a thin polycarbonate that’s completely transparent, so it’s almost as if you don’t even have a case around your iPhone. The edges are made of a slim rubber, making it easy to install and remove when necessary. Even the side buttons are raised for easy access!



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EU ruling allows Apple to trademark its store layouts

Love or hate them, it’s hard to argue that Apple’s retail stores aren’t highly distinctive. That’s what the EU’s highest court thought when it overruled a German verdict and said that Apple’s store design could be registered as a trademark in Europe….

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Vz37T2-8ixs/
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Cruise aims to make a self-driving car out of one you already own

We’re plummeting headlong into a future of cars that move without us, and you may not have to buy a brand new ride to be a part of it. You see, a startup called Cruise has been showing off a working prototype of its aftermarket RP-1 kit, and it aims…

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/jOoM-GIA0F0/
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Disneyland From Above, In 1955 and 2014

Disneyland From Above, In 1955 and 2014

Over on Southland, Nathan Masters shares incredible images that illustrate how Disneyland has changed over the last 59 years, going from an oasis amid endless orange groves to an oasis amid endless sprawl.

Read more…



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Airbnb announced today that it will begin charging San Francisco’s 14 percent hotel tax on reservati

Airbnb announced today that it will begin charging San Francisco’s 14 percent hotel tax on reservations in the city, starting this summer. The taxes will be paid by guests. Last week, the company announced a different partnership in Portland, Oregon, where Airbnb itself will pay some city taxes.

Read more…

    



Source: http://feeds.gawker.com/~r/gizmodo/full/~3/w69kI0fPz7E/airbnb-announced-today-that-it-will-begin-charging-san-1555778307
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Onboard JetBlue’s first Fly-Fi flight, with the fastest internet in the air

On a flight yesterday from JFK to Austin, JetBlue finally decided to flip the switch on Fly-Fi, giving lucky passengers an early look at the airline’s next-generation in-flight WiFi for the very first time. A flight attendant announced the service — which is free until 30 planes are retrofitted — and passengers seated around me pulled out their laptops, tablets and smartphones and tried to hop online. Unfortunately, a recent update caused unexpected performance issues, and Fly-Fi’s speed and consistency fell far short. When a flight attendant asked the woman seated in front if me if she had enjoyed her experience at the end of the flight, she responded with “not so much.” It wasn’t looking good for JetBlue.

I had booked my return to New York on the same aircraft, and following a 20-minute BBQ pitstop at AUS, I got back on board. The issues we experienced on the first flight — allegedly caused by an incorrect DNS-server listing on the network side — were completely resolved, making our three-hour hop back to Kennedy Airport much more pleasant. The experience was completely different, though we were offline for 30 minutes or so as we passed over Louisiana and Mississippi. Ultimately, Fly-Fi, which utilizes the ViaSat-1 satellite positioned over North America, was in line with the ViaSat service I’ve tried on the ground — when it works, it blows the competition out of the water. It’s as close as you’ll get to the internet you’re used to at home, and it certainly outshines connectivity in pretty much any airline terminal.

JetBlue’s LiveTV subsidiary, which installs and supports the service, quoted speeds of 12 Mbps per passenger during our tour back in September. It’s an ambitious figure, and with 100 passengers streaming Netflix and Hulu, that promise might be a bit of a stretch. On yesterday’s flight from Austin, however, I had no problem loading picture-heavy websites and videos on YouTube after upgrading to Fly-Fi Plus, which currently costs $9 per hour (ouch!), but can be “paused” to maximize usage. I also completed tasks that you’re unlikely to conduct in the air, like transferring files to and from an FTP server and hosting a Google video Hangout with three friends. Audio was inconsistent during the Hangout and the data transfer was sluggish, but with ViaSat optimizing the network for video streaming, that’s to be expected.

Ordinary usage, like text chats with colleagues, loading hundreds of tweets, streaming music on Spotify and sending and receiving emails went off without a hitch, and were possible with the free service. I even sent some photos via email and HipChat, which were received quickly and without the nasty compression we’ve come to expect from current-gen Gogo. During a handful of speed tests, download bandwidth varied from 1 Mbps to 30 Mbps (most often falling around 15 Mbps), while upload bandwidth hovered around 0.5 Mbps.

ViaSat limits the uplink from each plane in order to maximize downloads. That helps to explain why attempted Skype and Google Voice calls failed, and while my friends looked fine in the Hangout, I appeared slightly pixelated on their computers. It’s also important to note that ViaSat-1 hovers some 22,000 miles above Earth, so an ~ 800-millisecond ping is to be expected. Upload speeds are unlikely to improve (so save those large file transfers for the ground), but that 12-megabits-per-seat figure we’ve heard seems reasonable with only a few dozen passengers online (and even fewer streaming HD video). The 30-minute outage we experienced should also be a non-issue by the time Fly-Fi exits beta, sometime within the next few weeks.

Following the hiccups during that first-ever Fly-Fi flight yesterday morning, I was a bit concerned about the program’s future. After taking it for a spin on the trip back, however, it was impossible not to get excited about the service’s potential, and the future of in-flight connectivity in general. LiveTV is currently working to outfit JetBlue’s fleet, and will soon launch the service on select United 737s as well. For now, you’ll only find the service on two of JetBlue’s workhorse A320s, but they’re not assigned to specific flights until a few days before departure, so don’t plan your holiday travel around trying out Fly-Fi. The airline may eventually identify flights in advance, and all A320s should be online by mid-2014. United hasn’t announced rollout plans just yet, but as LiveTV begins to retrofit that airline’s planes as well, it wouldn’t be unreasonable to expect a similar test in the weeks and months to come.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Act-SCJSlvI/
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Multicenter study underscored the need of a uniform approach to the treatment of BCa

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PUBLIC RELEASE DATE:

15-Nov-2013

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Contact: Evgenia Starkova
e.starkova@uroweb.org
31-263-890-680
European Association of Urology

Arnhem, The Netherlands – New study, involving eight Italian research centres, concluded that an aligned approach to the treatment of advanced bladder cancer is much needed, while confirming previously published results on survival estimates of associated salvage therapies.

According to the lead author, Dr. Francesco Atzori, progress in developing new effective drugs in bladder cancer has been stagnant in the last decades.

“In patients who recur or who are refractory to first-line therapy, response rates and outcomes are grim, and to date, no second-line therapy has been clearly established,” he explained.

The authors state that while upfront chemotherapy (CT) confers over 50% response rate, progression free survival and overall survival rates are still dismal. While vinflunine is approved by the EMA for progressive bladder cancer after platinum-based therapy, the US FDA has no approved agents.

In the course of the study, the researchers retrospectively queried all patients receiving 2nd and 3rd line regimens in Italy in the period between 2001 and 2013. The inclusion criteria included failure of one or two prior CT regimens for metastatic disease and no exclusion of specific salvage regiments, including targeted agents. Distribution of treatments and outcome parameters were the primary endpoints.

The authors identified a total of 160 eligible pts across 8 centers nationwide. Median age was 67 years (IQR 39-82), most frequent sites of disease at relapse were: nodes 71% (nodes only 43, 26.9%); lung 30%, bone 26% and liver 20%. Bellmunt Score available in 147 out of 160 patients was 0, 1, 2 and 3 in 63 (43%), 59 (40%), 20 (14%) and 5 (3%) patients respectively.

Regiments used as upfront CT were cisplatin-gemcitabine in 65 patients (41%), carboplatin-G in 50 patients (31%), MVAC in 25 patients (16%), other combination CT in 5 patients (3%) and single-agent CT in 15 patients (9%).

In 2nd line 42 patients (26%) received paclitaxel, 40 (25%) vinflunine, 21 (13%) pazopanib, 10 (6%) MVAC, 47 (29%) other drugs alone or combined.

75 out of 160 patients (47%) received a 3rd line regimen: 19 (25%) paclitaxel, 15 (20%) pazopanib, 11 (15%) MVAC, 30 patients (40%) miscellaneous. Median time-to-relapse to 1st line was 2 months. Overall response rate in 2nd line was 21% (32 out of 160 patients) and 21% in 3rd line (16 out of 75 patients); median progression-free survival was 2,8 and 2 months in 2nd and 3rd line respectively, median overall survival was 16 months and 20 months, in 2nd and 3rd lines respectively. Patients treated with paclitaxel and vinflunine in 2nd line showed a median progression free survival of 2.7 and 3.3 months while overall survival was 13.5 and 13.4 months respectively.

The results of this study will be presented at the European Multidisciplinary Meeting on Urological Cancers, in Marceille, France, on 15-17 November 2013.

###

Reference: Francesco Atzori et al, Efficacy of second and third-line chemotherapy in patients with advanced transitional-cell carcinoma: Results of a national multicentre pooled analysis, Abstract O3, 5th EMUC.



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[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

15-Nov-2013

[

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]


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Contact: Evgenia Starkova
e.starkova@uroweb.org
31-263-890-680
European Association of Urology

Arnhem, The Netherlands – New study, involving eight Italian research centres, concluded that an aligned approach to the treatment of advanced bladder cancer is much needed, while confirming previously published results on survival estimates of associated salvage therapies.

According to the lead author, Dr. Francesco Atzori, progress in developing new effective drugs in bladder cancer has been stagnant in the last decades.

“In patients who recur or who are refractory to first-line therapy, response rates and outcomes are grim, and to date, no second-line therapy has been clearly established,” he explained.

The authors state that while upfront chemotherapy (CT) confers over 50% response rate, progression free survival and overall survival rates are still dismal. While vinflunine is approved by the EMA for progressive bladder cancer after platinum-based therapy, the US FDA has no approved agents.

In the course of the study, the researchers retrospectively queried all patients receiving 2nd and 3rd line regimens in Italy in the period between 2001 and 2013. The inclusion criteria included failure of one or two prior CT regimens for metastatic disease and no exclusion of specific salvage regiments, including targeted agents. Distribution of treatments and outcome parameters were the primary endpoints.

The authors identified a total of 160 eligible pts across 8 centers nationwide. Median age was 67 years (IQR 39-82), most frequent sites of disease at relapse were: nodes 71% (nodes only 43, 26.9%); lung 30%, bone 26% and liver 20%. Bellmunt Score available in 147 out of 160 patients was 0, 1, 2 and 3 in 63 (43%), 59 (40%), 20 (14%) and 5 (3%) patients respectively.

Regiments used as upfront CT were cisplatin-gemcitabine in 65 patients (41%), carboplatin-G in 50 patients (31%), MVAC in 25 patients (16%), other combination CT in 5 patients (3%) and single-agent CT in 15 patients (9%).

In 2nd line 42 patients (26%) received paclitaxel, 40 (25%) vinflunine, 21 (13%) pazopanib, 10 (6%) MVAC, 47 (29%) other drugs alone or combined.

75 out of 160 patients (47%) received a 3rd line regimen: 19 (25%) paclitaxel, 15 (20%) pazopanib, 11 (15%) MVAC, 30 patients (40%) miscellaneous. Median time-to-relapse to 1st line was 2 months. Overall response rate in 2nd line was 21% (32 out of 160 patients) and 21% in 3rd line (16 out of 75 patients); median progression-free survival was 2,8 and 2 months in 2nd and 3rd line respectively, median overall survival was 16 months and 20 months, in 2nd and 3rd lines respectively. Patients treated with paclitaxel and vinflunine in 2nd line showed a median progression free survival of 2.7 and 3.3 months while overall survival was 13.5 and 13.4 months respectively.

The results of this study will be presented at the European Multidisciplinary Meeting on Urological Cancers, in Marceille, France, on 15-17 November 2013.

###

Reference: Francesco Atzori et al, Efficacy of second and third-line chemotherapy in patients with advanced transitional-cell carcinoma: Results of a national multicentre pooled analysis, Abstract O3, 5th EMUC.



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Source: http://www.eurekalert.org/pub_releases/2013-11/eaou-msu111213.php
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Miley Cyrus Featured in “Styled to Rock” Promo: Watch Here!

Ready to add “judge” to her resume, Miley Cyrus will appear on the next episode of the fashion reality competition “Styled to Rock.”

Created by fellow songstress Rihanna, the show is described as “contestants aim to create a new look to define the celebrity guest’s image, and in turn battle it out in the sewing room.”

Not keeping the fun to herself, Miley brought a helper to the set- her mom Tish, who helped her judge the competition.

“Styled to Rock” airs on Friday at 8/7 central on Bravo. Check out a preview of Miley’s appearance below!

Source: http://celebrity-gossip.net/miley-cyrus/miley-cyrus-featured-styled-rock-promo-watch-here-959516
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